Iran and the United States prepared for a fifth round of negotiations over Tehran’s rapidly advancing nuclear program Friday in Rome, with enrichment emerging as the key issue.

US officials up to President Donald Trump insist Iran cannot continue to enrich uranium at all in any deal that could see sanctions lifted on Tehran’s struggling economy.

Iran’s Foreign Minister Abbas Araghchi early Friday insisted online that no enrichment would mean “we do NOT have a deal.”

Separately, in a letter to the UN on Thursday, Araghchi warned that Iran could hide its nuclear material, amid threats of an Israeli strike on its facilities.

During the talks, the US will again be represented by Mideast envoy Steve Witkoff and Michael Anton, the State Department’s policy planning director.